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Biomateriais em Medicina: do fabrico ao doente

Code:

OPT206

Acronym:

BM:FD

Keywords
Classification	Keyword
OFICIAL	Medicine

Instance: 2022/2023 - 2S

Active?	No
Responsible unit:	Departamento de Patologia
Course/CS Responsible:	Integrated Master in Medicine

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIMED	0	Plano Oficial 2021	5	-	2	19	54

Teaching language

Portuguese

Objectives

Learning outcomes of the curricular unit:

The optional curricular unit Biomaterials in Medicine: from the product to the patient aims to provide a multidisciplinary knowledge of future doctors in the field of biomaterials and their varied applications in Medicine.

At the end of the UC the student will be able to:

• recognize the importance of biomaterials in Medicine

• acquire knowledge of technological advances in the manufacture of biomaterials

• acquire knowledge regarding the epidemiology, epidemiology and diagnosis of infections associated with biomaterials

• recognize biomaterial benefits and limitations that may influence its performance in practical practice

• Develop an experimental study to evaluate the performance of biomaterials

• Evaluate the characteristics of new state-of-the-art evaluation materials

Learning outcomes and competences

The content covers major and current clinical topics in the field of medical implants, their manufacture, testing and applicability in clinical practice. The combination of different pedagogical modalities with a teaching team with multidisciplinary skills, will allow students to experience 3D printing in the manufacture of biomaterials, laboratory experimentation and discussion of clinical cases. With the accomplishment of the activities in the program, it will be expected that the students acquire the competences in this UC.

Working method

Presencial

Program

Introduction to the curricular unit. Biomaterials: different types and applications. (1h/T)

Manufacturing processes: 3D printing (1h/S)

From design to additive manufacturing (2h/TP)

Application of biomaterials in Medicine: Case studies (2h/T)

Biomaterials associated infections: etiopathology, risk factors and epidemiology (1h/T)

Biofilm formation and antimicrobial resistance (1h/T)

Contribution of the Microbiology laboratory in the diagnosis of infection (1h/T)

Performance evaluation of biomaterials: cytocompatibility assays (2h/ PL)

Performance evaluation of biomaterials: adhesion assays and biofilm formation (2h/PL)

Performance evaluation of biomaterials in animal models (2h/T)

Tutorial guidance (2h/OT)

Presentation and discussion of scientific articles (2h/T)

Mandatory literature

José C. C. Paiva, Luís Oliveira, Maria Fátima Vaz and Sofia Costa-de-Oliveira; Biodegradable Bone Implants as a New Hope to Reduce Device-Associated Infections—A Systematic Review, 2022
Li, Z., Wang, Q., & Liu, G. ; A Review of 3D Printed Bone Implants., 2022
Wong, K. C. ; 3D-printed patient-specific applications in orthopedics. , 2016
Depypere, M., Morgenstern, M., Kuehl, R., Senneville, E., Moriarty, T. F., Obremskey, W. T., Zimmerli, W., Trampuz, A., Lagrou, K., & Metsemakers, W. J. ; Pathogenesis and management of fracture-related infection. , 2019
Hall, C. W., & Mah, T. F. ; Molecular mechanisms of biofilm-based antibiotic resistance and tolerance in pathogenic bacteria. , 2017

Teaching methods and learning activities

The involvement of students in UC activities will allow a transversal knowledge in the science of biomaterials and their usefulness in Medicine, providing a link between Health Sciences and Engineering. The strategy outlined by the faculty will boost the development of critical and scientific thinking by students, placing them in the face of challenges arising from clinical practice.

This curricular unit, with 2 ECTS, provides for 54 hours of total work and will be taught in a block with 19 hours of contact distributed between lectures, seminars, tutorial guidance and laboratory practices. In this last modality, it may be necessary to create shifts since the capacity of the laboratories is limited. The UC will take place in the 2nd semester of the 5th year of the Integrated Master in Medicine and will last for 12 weeks.

Lecturess (8 hours) and seminars (3 hours) will be supported by slides in PowerPoint format, which will be available on FMUP's Sigarra and Moodle platforms. Discussion will be promoted, involving the presentation, for 10 minutes of examples by the students, based on bibliographic research regarding the UC.

The theoretical-practical class (2 hours) will take place at the Institute of Science and Innovation in Engineering (INEGI), where students will be able to experience the methods of manufacturing biomaterials, namely 3D printing.

The practical classes (4h) are a complement to the theoretical classes, allowing students to have direct contact with the laboratory methods used in Microbiology, regarding the testing of biomaterials. They may also participate in some laboratory activities resulting from research projects in biomaterials.

This UC provides 2 hours of tutorial guidance, to prepare students for the presentation and final discussion, which will be the object of evaluation.

All classes will be taught in person, and this modality can be changed due to the epidemiological evolution of COVID19.

Evaluation Type

Distributed evaluation without final exam

Assessment Components

Designation	Weight (%)
Participação presencial	50,00
Apresentação/discussão de um trabalho científico	50,00
Total:	100,00

Amount of time allocated to each course unit

Designation	Time (hours)
Apresentação/discussão de um trabalho científico	2,00
Estudo autónomo	35,00
Frequência das aulas	17,00
Total:	54,00

Eligibility for exams

Frequency acquisition

Obtaining frequency will be in accordance with the pedagogical regulation, which requires a minimum presence in 75% of classes.

Calculation formula of final grade

Final classification calculation formula

Final classification = (PP*0.5) + (TE*0.5)

On what:

PP – face-to-face participation

TE - assessment obtained in the oral work

Continuous assessment during contact hours by the respective professors, weighted by 50% in the final classification and distributed as follows: 0.1*participation and scientific interest + 0.1*commitment and initiative + 0.2*understanding of the methodology practiced + 0.1*attendance.

Oral presentation of 10 minutes and discussion of a scientific article within the scope of the objectives of the curricular unit weighted by 50% in the final classification.

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