Introduction to research in molecular pathology applied in oncology

Code:

OPT18

Acronym:

IIPMO14

Keywords
Classification	Keyword
OFICIAL	Medicine

Instance: 2022/2023 - 1S

Active?	Yes
Responsible unit:	Departamento de Patologia
Course/CS Responsible:	Integrated Master in Medicine

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIMED	1	Plano Oficial 2021	3	-	2	19	54

Teaching language

Suitable for English-speaking students

Objectives

 

-Indicate the cellular characteristics of the neoplastic cells

- Describe the cellular characteristics of the neoplastic cells

- Identify appropriate methodologies for the study of the various cellular characteristics

- Explain the theoretical basis of the  methodologies

- Experiment techniques for the evaluation of neoplastic cells characteristics

- Distinguish the limitations of the various methodologies

- Explain the various cellular and animal models for cancer research 

- Identify the limitations of the various cellular and animal models for cancer research

- Planning experimental approaches to the study of a certain cellular characteristic

- Interpret results obtained in the various experimental approaches 

Learning outcomes and competences

At the end of the UC students should be empowered with tools for description and analysis suitable for both, the understanding of laboratory practices in the areas of basic and translational research in oncology and the development of their research projects.

Working method

Presencial

Pre-requirements (prior knowledge) and co-requirements (common knowledge)

Completed attendance of the CU of the 1st semester of the 2nd year of MIMED in which the contents of cell cycle and apoptosis are taught

Program

1.        Introduction - Cancer hallmarks


2.        Proliferation and apoptosis in cancer


3.        Genetic susceptibility and instability in cancer


4.        Infection in cancer


5.        Cellular metabolism in cancer


6. Experimental models in cancer research      

Mandatory literature

Cláudio Sunkel e Carlos Azevedo Editores(5.ª Edição), Lidel.; Biologia Celular e Molecular, Capitulo “ A célula neoplásica”, Lidel.
Hanahan D, Weinberg RA; Hallmarks of cancer

Complementary Bibliography

Hanahan D, Weinberg RA; . Hallmarks of cancer: the next generation.

Teaching methods and learning activities

Five sessions, 3,5 hours each, including a short theoretical introduction(30 mn), laboratorial practice (3h) 

The sessions will be organized to focus on the practical component. A short theoretical introduction attempts to fit the contents of the session on the problems of research or diagnostic pathology. The starting point for the laboratory activities will be information obtained from specific research projects ongoing in the lab or, preferably, projects in which students are involved (eg work of the integrated master's thesis).

Priority will be given to practical methods, active and demonstrative, which will be complemented by short moments of expository presentation and discussion of theoretical and methodological concepts.

Each session will end with a short discussion of the methodological approaches experienced, discussion of the results, applications, limitations and possible artifacts.

 

Note - in view of the current contingency situation, there may be a need
to adapt some of the contents of the UC, namely the conversion of some 
practical classes into theoretical-practical classes. There may also be
 recourse to recorded or synchronized classes by ZOOM

keywords

Health sciences
Natural sciences > Biological sciences > Biology > Genetics
Natural sciences > Biological sciences > Biology > Molecular biology
Health sciences > Medical sciences > Medicine > Pathological anatomy
Health sciences > Medical sciences > Medicine > Oncology

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Designation	Weight (%)
Exame	90,00
Participação presencial	10,00
Total:	100,00

Amount of time allocated to each course unit

Designation	Time (hours)
Apresentação/discussão de um trabalho científico	2,00
Frequência das aulas	19,00
Estudo autónomo	27,00
Trabalho laboratorial	6,00
Total:	54,00

Eligibility for exams

Participate in 4 lessons, that correspond to 80% of the sessions

Calculation formula of final grade

Written examination: Test with multiple-choice questions, association questions and open questions with short answer. The classification will be express in a scale from 0 to 20.