Reprogramming stem cells and carcinogenesis
Keywords |
Classification |
Keyword |
OFICIAL |
Medicine |
Instance: 2019/2020 - 2S (of 10-02-2020 to 31-07-2020)
Cycles of Study/Courses
Teaching language
Portuguese and english
Objectives
- To identify the main features of neoplasias.
- To distinguish embryonic stem cells, adult stem cells and iPS cells.
- To relate regeneration, transdifferentiation and metaplasia.
- To identify the pathological conditions in which they occur.
- To understand an example of a pathological condition where regeneration and transdifferentiation predispose to cancer.
- To identify other regenerative conditions.
- To identify preneoplastic lesions, regenerative and with transdifferentiation through histological and immunohistochemical observation.
- To identify the concept of cancer stem cells.
- To discuss what are the potential applications of stem cells for tissue regeneration, in reference to Regenerative Medicine.
Learning outcomes and competences
The curricular unit includes topics intended at the understanding of how regenerative conditions as well as stem cell reprogramming predispose to cancer, using different examples both in human pathological situations and in animal models. To better understand these mechanisms, topics focusing on basic aspects of stem cell biology and the state of the art on stem cell reprogramming in the context of regenerative medicine were included. The discussion of how this reprogramming leads to cancer will be promoted through the presentation of articles published in peer-reviewed journals. The theoretical part will be complemented by a practical class in which the pathological conditions under study will be visualized under the microscope.
Working method
Presencial
Program
Introduction to oncobiology.
Stem cells and tissue homeostasis.
Regeneration, transdifferentiation and metaplasia.
Cellular reprogramming and carcinogenesis.
Examples of pathological conditions that harbour some or all of these processes.
Intestinal metaplasia: an example of a regenerative condition, with transdifferentiation that predisposes to cancer.
Cancer stem cells.
Stem cell therapies.
Mandatory literature
Robbins and Conan ; Pathologic basis of disease
Alberts, Johnson, Lewis, Morgan, raff, Roberts, Walter; Molecular Biology of the Cell
Teaching methods and learning activities
Lectures and Seminars
Evaluation: Written exam - Test with multiple-choice questions and short answer questions
Evaluation Type
Evaluation with final exam
Assessment Components
Designation |
Weight (%) |
Exame |
100,00 |
Total: |
100,00 |
Amount of time allocated to each course unit
Designation |
Time (hours) |
Estudo autónomo |
27,00 |
Frequência das aulas |
14,00 |
Total: |
41,00 |
Eligibility for exams
Attendance of 75% of the classes + exam
Calculation formula of final grade
The final classification will be the one obtained in the exam.