Mitochondrial Alterations and Disease
Keywords |
Classification |
Keyword |
OFICIAL |
Medicine |
Instance: 2019/2020 - 2S (of 10-02-2020 to 31-07-2020) ![Requerida a integração com o Moodle Ícone do Moodle](/fmup/pt/imagens/MoodleIcon)
Cycles of Study/Courses
Teaching language
Suitable for English-speaking students
Objectives
1. To consolidate the learning of normal mitochondrial physiology
2. To understand the key molecular mechanisms of mitochondrial dysfunction
3. To understand how to use the molecular mechanisms of mitochondrial dysfunction for diagnosing concrete clinical situations, namely degenerative and neoplastic diseases.
4. To understand how to use the molecular mechanisms of mitochondrial dysfunction in the aging process and in its relationship with neurodegenerative diseases.
5. To learn how to use the molecular diagnosis of mitochondrial disorders in the development of new therapies.
Learning outcomes and competences
The syllabus includes topics that allow the understanding the origin, structure and morphology, biogenesis regulation and the mitochondrial function, as well as the integration of mitochondrial metabolism in the context of cellular metabolism. In addition, the program will allow the understanding of the pathogenesis of mitochondrial diseases and their relationship with aging and cancer, and the identification of the molecular alterations that may be used as therapeutic targets.
Working method
Presencial
Program
I – Brief historical review
II - Mitochondrial structure and morphology
III - Mitochondrial biogenesis
IV – Mitochondrial respiratory chain and oxidative phosphorylation
V - Metabolic pathways
VI - Mitochondrial DNA-genetics and heredity
VII - Mitochondrial diseases
VIII – Aging and mitochondria
IX - Mitochondria and cancer
X - Mitochondria and pharmacology
Mandatory literature
Lemasters, J.J. and A.L.; Mitochondria in Pathogenesis, Springer, 2001. ISBN: 0306464330
Complementary Bibliography
Gvozdjáková, A.; Mitochondrial Medicine: Mitochondrial Metabolism, Diseases, Diagnosis and Therapy. 2008, Springer, 2008. ISBN: 978-1-4020-6714-3
Teaching methods and learning activities
Lectures, Seminars, and Sessions of discussion of scientific papers.
keywords
Health sciences > Medical sciences
Evaluation Type
Distributed evaluation with final exam
Assessment Components
Designation |
Weight (%) |
Exame |
75,00 |
Apresentação/discussão de um trabalho científico |
25,00 |
Total: |
100,00 |
Amount of time allocated to each course unit
Designation |
Time (hours) |
Estudo autónomo |
16,50 |
Frequência das aulas |
14,00 |
Trabalho de investigação |
10,00 |
Total: |
40,50 |
Eligibility for exams
Presence in 75 of the Seminars.
Calculation formula of final grade
Final evaluation (20 Values) = Classification of the written exam (20 Values) * 0.75 + Presentation/discussion for a scientific project (20 values) * 0.25