Mitochondrial Alterations and Disease

Code:

OPT01

Acronym:

AMD

Keywords
Classification	Keyword
OFICIAL	Medicine

Instance: 2019/2020 - 2S (of 10-02-2020 to 31-07-2020)

Active?	Yes
Responsible unit:	Departamento de Patologia
Course/CS Responsible:	Integrated Master in Medicine

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIMED	16	Mestrado Integrado em Medicina- Plano oficial 2013 (Reforma Curricular)	2	-	1,5	14	40,5
			3

Teaching language

Suitable for English-speaking students

Objectives

1. To consolidate the learning of normal mitochondrial physiology
2. To understand the key molecular mechanisms of mitochondrial dysfunction
3. To understand how to use the molecular mechanisms of mitochondrial dysfunction for diagnosing concrete clinical situations, namely degenerative and neoplastic diseases.
4. To understand how to use the molecular mechanisms of mitochondrial dysfunction in the aging process and in its relationship with neurodegenerative diseases.
5. To learn how to use the molecular diagnosis of mitochondrial disorders in the development of new therapies.

Learning outcomes and competences

The syllabus includes topics that allow the understanding the origin, structure and morphology, biogenesis regulation and the mitochondrial function, as well as the integration of mitochondrial metabolism in the context of cellular metabolism. In addition, the program will allow the understanding of the pathogenesis of mitochondrial diseases and their relationship with aging and cancer, and the identification of the molecular alterations that may be used as therapeutic targets.

Working method

Presencial

Program

I – Brief historical review
II - Mitochondrial structure and morphology
III - Mitochondrial biogenesis
IV – Mitochondrial respiratory chain and oxidative phosphorylation
V - Metabolic pathways
VI - Mitochondrial DNA-genetics and heredity
VII - Mitochondrial diseases
VIII – Aging and mitochondria
IX - Mitochondria and cancer
X - Mitochondria and pharmacology

Mandatory literature

Lemasters, J.J. and A.L.; Mitochondria in Pathogenesis, Springer, 2001. ISBN: 0306464330

Complementary Bibliography

Gvozdjáková, A.; Mitochondrial Medicine: Mitochondrial Metabolism, Diseases, Diagnosis and Therapy. 2008, Springer, 2008. ISBN: 978-1-4020-6714-3

Teaching methods and learning activities

Lectures, Seminars, and Sessions of discussion of scientific papers.

keywords

Health sciences > Medical sciences

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Designation	Weight (%)
Exame	75,00
Apresentação/discussão de um trabalho científico	25,00
Total:	100,00

Amount of time allocated to each course unit

Designation	Time (hours)
Estudo autónomo	16,50
Frequência das aulas	14,00
Trabalho de investigação	10,00
Total:	40,50

Eligibility for exams

Presence in 75 of the Seminars.

Calculation formula of final grade

Final evaluation (20 Values) = Classification of the written exam (20 Values) * 0.75 + Presentation/discussion for a scientific project (20 values) * 0.25