Cytogenetics and Cell Cycle

Code:

MI222

Acronym:

CCC

Keywords
Classification	Keyword
OFICIAL	Medicine

Instance: 2019/2020 - 1S (of 09-09-2019 to 09-02-2020)

Active?	Yes
Responsible unit:	Departamento de Patologia
Course/CS Responsible:	Integrated Master in Medicine

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIMED	258	Mestrado Integrado em Medicina- Plano oficial 2013 (Reforma Curricular)	2	-	3	25	81

Teaching language

Portuguese

Objectives

Acquire basic knowledge about: (A) cell cycle regulation, cell division and molecular processes underlying differentiation, dedifferentiation and cellular aging; (B) cytogenetic techniques and basic concepts on structure and function of chromosomes, (C) etiopathogenesis of chromosomal pathology, preparing students to acquire knowledge related to genetic transmission of chromosomal disorders and genetic risk assessment. Additionally it is intended that students be able to critically evaluate scientific literature and apply the basic principles of the scientific research in biology and genetics.

Learning outcomes and competences

The program integrates the fundamental knowledge of cell biology and genetics, to correlate the knowledge with clinical manifestations of genetic disorders namely the chromosomal pathology.

Working method

Presencial

Program

Cell cycle I - molecular regulation of interphase
Cell Cycle II - Mitosis
cellular aging
Apoptosis
Chromosomal pathologies
Meiotic division, gametes and fertilization
Chromosomes and chromosomal abnormalities of number and structure
Pathology of cell division and meiotic configurations
Cytogenetic techniques I
Cytogenetic techniques II
Cancer cytogenetics
Chromosomal instability syndromes

Mandatory literature

Peter Turnpenny, Sian Ellard; Emery's Elements of Medical Genetics. ISBN: 9780702040436
Cooper, G.M. & Hausman; The Cell: A Molecular Approach , R.E. ASM Press, 2013. ISBN: 978-1-60535-155-1

Complementary Bibliography

Gardner, Sutherland and Shaffer; Chromosome abnormalities and genetic counseling , Oxford, 2012. ISBN: 9780195375336
Gersen and Keagle; The principles of clinical genetics , Humana Press, 2013. ISBN: 978-1-4419-1688-4
Pollard & Earnshaw; Cell Biology, Elsevier, 2007. ISBN: 978-1-4160-2255-8

Teaching methods and learning activities

Lectures (13hours) and laboratory sessions (12 hours).

The practical classes will include microscopic observation and the realization of some major cytogenetic techniques practiced in Genetics Laboratories. It Will allow students a more practical contact with the topics covered in the lectures.

 

keywords

Natural sciences > Biological sciences > Biology > Human biology
Health sciences
Natural sciences > Biological sciences > Biology > Genetics
Natural sciences > Biological sciences > Biology > Cell biology

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Designation	Weight (%)
Exame	90,00
Teste	10,00
Total:	100,00

Amount of time allocated to each course unit

Designation	Time (hours)
Estudo autónomo	56,00
Frequência das aulas	25,00
Total:	81,00

Eligibility for exams

Participation in 5 of the 6 practical classes

Calculation formula of final grade

Evaluation: Final exam (FE) + pratical teste (PT)


The practical component  will be evaluated by an assessment test that will take place at the end of the practical classes, in a single exam for all students, and no new oportunity will be available.  Failure  this evaluation will imply that the student assigns 0 values from 2 possible values. It was not considered a minimum mark in the practical test but the student should take into account that this evaluation was attributed to the valuation of 1/10 of the final mark.



1. (FE) Final exam  (20 marks):

Part I – 15 marks . It includes 30 multiple-choice questions (each 0.4 marks, quoted to 12 marks) + 20 true-false questions (each 0.15 marks, quoted to 3 marks);

Part II - 5 marks. Short answer questions 

2. (PT) Evaluation of practical classes (20 marks) - Evaluation focused in in pratical issues

Final assessment: Students must reach a minimal classification of 9.5 (out of 20).
Calculation=0,9FRE+0,1PT marks

Classification improvement

Possible