Code: | OPT22 | Acronym: | MMMP14 |
Keywords | |
---|---|
Classification | Keyword |
OFICIAL | Medicine |
Active? | Yes |
Responsible unit: | Departamento de Biologia Experimental |
Course/CS Responsible: | Integrated Master in Medicine |
Acronym | No. of Students | Study Plan | Curricular Years | Credits UCN | Credits ECTS | Contact hours | Total Time |
---|---|---|---|---|---|---|---|
MIMED | 13 | Mestrado Integrado em Medicina- Plano oficial 2013 (Reforma Curricular) | 2 | - | 3 | 27 | 81 |
Personalized medicine aims to provide precise and personalized diagnosis of patients, in order to conduct individualized therapy. It is in its early stages of implementation into European healthcare market and one of the main barriers to its development is the lack of knowledge among healthcare providers. Therefore, this curricular unit focuses on personalized medicine and integrates advanced molecular technologies, fundamental to its understanding. Educating medical students on the methodological science of genomics, proteomics, bioinformatics and molecular imaging techniques, will be essential to the development of new therapies that are targeted to the individual patient. Students will face this new healthcare paradigm and will be challenged to a theoretical implementation of the personalized medicine practice.
1-The Future of Medicine: Molecules or Persons?
Essential principles of Personalized Medicine
The patient as a genetic individuality
Clinical cases
Therapy based on molecular diagnostic
Challenges in Personalized Medicine
2- Molecular dissection of the patient
Technology platforms for genomic Medicine
Exome sequencing; Microarrays; “Single nucleotide polimorphisms” (SNPs); ; genetic expression; epigenomics
Proteomics and identification of disease biomarkers
Protein array; mass spectrometry; isoelectric focusing ; bidimensional electrophoresis
Molecular Imaging in Medicine
Fluorescence microscopy; live-imaging microscopy; Fluorescence resonance energy transfer (FRET) ; Fluorescence recovery after photobleaching (FRAP)
3- Clinic Bioinformatics
Computational plataforms for Genomic Medicine (Genome browser, single-nucleotide polymorphism (SNP) database; International HapMap Project )
4-Genetic manipulation on personalized therapy
Stem cells; Recombinant proteins; cell culture; Interference RNA; microRNAs
Syllabus- laboratorial classes:
-Clinical bioinformatics
- Genetic manipulation in human cell culture models
- Microscopic analysis and quantification of biomarkers expression
The lesson plan comprises 11 lectures, lasting one hour each, and 5 practical classes, 3 hours each. These hands-on practical classes will always be supervised by a teacher. Students will be divided in 5 small groups to ensure adequate high-quality learning environment and practical classes will take place in a fully equipped molecular biology laboratory. Furthermore, students will present a scientific paper in a journal club session (1 hour) in order to evaluate their knowledge on molecular biology techniques and their critical thinking in the context of personalized medicine.
Designation | Weight (%) |
---|---|
Participação presencial | 50,00 |
Prova oral | 50,00 |
Total: | 100,00 |
Designation | Time (hours) |
---|---|
Frequência das aulas | 11,00 |
Trabalho laboratorial | 15,00 |
Total: | 26,00 |