Lipophilic phenolic antioxidants: Correlation between antioxidant profile, partition coefficients and redox properties

• Type: Article in International Scientific Journal
• Date: 2010

Authors

Roleira, FMF (Author) Other; Christophe Siquet (Author) Other; Orru, E (Author) Other; Manuela Garrido, EM (Author) Other; Garrido, J (Author) Other; Milhazes, N (Author) Other; Podda, G (Author) Other; Fatima Paiva Martins (Author) FCUP; Salette Reis (Author) FFUP; Carvalho, RA (Author) Other; Tavares da Silva, EJT (Author) Other; Fernanda Borges (Author) FCUP

Journal

Title: Bioorganic and Medicinal Chemistry

Vol. 18

Pages: 5816-5825

ISSN: 0968-0896

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 90 Citations

Scopus - 98 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-003-3ZE

DOI: 10.1016/j.bmc.2010.06.090

Abstract (EN): Lipophilic compounds structurally based on caffeic, hydrocaffeic, ferulic and hydroferulic acids were synthesized. Subsequently, their antioxidant activity was evaluated as well as their partition coefficients and redox potentials. The structure-property-activity relationship (SPAR) results revealed the existence of a clear correlation between the redox potentials and the antioxidant activity. In addition, some compounds showed a proper lipophilicity to cross the blood-brain barrier. Their predicted ADME properties are also in accordance with the general requirements for potential CNS drugs. Accordingly, one can propose these phenolic compounds as potential antioxidants for tackling the oxidative status linked to the neurodegenerative processes.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10