Salvia Fruticosa, Salvia Officinalis, and Rosmarinic Acid Induce Apoptosis and Inhibit Proliferation of Human Colorectal Cell Lines: The Role in MAPK/ERK Pathway

• Type: Article in International Scientific Journal
• Date: 2009

Authors

Cristina P R Xavier (Author) Other; Cristovao F Lima (Author) Other; Manuel Fernandes Ferreira (Author) Other; Cristina Pereira Wilson (Author) Other

Journal

Title: Nutrition and Cancer

Vol. 61

Pages: 564-571

ISSN: 0163-5581

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 114 Citations

Scopus - 132 Citations

Scientific classification

FOS: Medical and Health sciences > Health sciences

Other information

Authenticus ID: P-003-RGW

DOI: 10.1080/01635580802710733

Abstract (EN): Epidemiological studies have shown that nutrition is a key factor in modulating sporadic colorectal carcinoma (CRC) risk. Aromatic plants of the genus Salvia (sage) have been attributed many medicinal properties, which include anticancer activity. In the present study, the antiproliferative and proapoptotic effects of water extracts of Salvia fruticosa (SF) and Salvia officinalis (SO) and of their main phenolic compound rosmarinic acid (RA) were evaluated in two human colon carcinoma-derived cell lines, HCT15 and CO115, which have different mutations in the MAPK/ERK and PI3K/Akt signalling pathways. These pathways are commonly altered in CRC, leading to increased proliferation and inhibition of apoptosis. Our results show that SF, SO, and RA induce apoptosis in both cell lines, whereas cell proliferation was inhibited by the two sage extracts only in HCT15. SO, SF, and RA inhibited ERK phosphorylation in HCT15 and had no effects on Akt phosphorylation in CO115 cells. The activity of sage extracts seems to be due, at least in part, to the inhibition of MAPK/ERK pathway.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8