MicroRNA regulation of core apoptosis pathways in cancer

• Type: Another Publication in an International Scientific Journal
• Date: 2011

Authors

Raquel T Lima (Author) Other; Sara Busacca (Author) Other; Gabriela M Almeida (Author) Other; Giovanni Gaudino (Author) Other; Dean A Fennell (Author) Other; Helena Vasconcelos, MH (Author) FFUP

Journal

Title: European Journal of Cancer

Vol. 47 No. 2

Pages: 163-174

ISSN: 0959-8049

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 215 Citations

Scopus - 225 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-002-YDQ

DOI: 10.1016/j.ejca.2010.11.005

Abstract (EN): Recent research has demonstrated that microRNAs (miRNAs) are key regulators of many cell processes often deregulated in cancer, including apoptosis. Indeed, it is becoming clear that many miRNAs are anti-apoptotic and mediate this effect by targeting pro-apoptotic mRNAs or positive regulators of pro-apoptotic mRNAs. Conversely, many pro-apoptotic miRNAs target anti-apoptotic mRNAs or their positive regulators. We have reviewed the current knowledge in this area including evidence of miRNA involvement in cancer drug resistance.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12