Lysine-based surfactants as chemical permeation enhancers for dermal delivery of local anesthetics

• Type: Article in International Scientific Journal
• Date: 2014

Authors

Raquel S Teixeira (Author) Other; Tania F G G Cova (Author) Other; Sergio M C Silva (Author) Other; Rita Oliveira (Author) Other; Maria J Araujo (Author) FCUP; Eduardo F Marques (Author) FCUP; Alberto A C C Pais (Author) Other; Francisco J B Veiga (Author) Other

Journal

Title: International Journal of Pharmaceutics

Vol. 474

Pages: 212-222

ISSN: 0378-5173

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 20 Citations

Scopus - 22 Citations

Scientific classification

FOS: Natural sciences > Biological sciences

Associated Projects

115212_2009 - Uma nova abordagem à veiculação de fármacos: lipossomas cataniónicos e nanotubos baseados em derivados de aminoácidos

Other information

Authenticus ID: P-009-VB8

DOI: 10.1016/j.ijpharm.2014.08.002

Abstract (EN): The aim of this study is to investigate the efficacy of new, biocompatible, lysine-based surfactants as chemical permeation enhancers for two different local anesthetics, tetracaine and ropivacaine hydrochloride, topically administered. Results show that this class of surfactants strongly influences permeation, especially in the case of the hydrophilic and ionized drug, ropivacaine hydrochloride, that is not easily administered through the stratum corneum. It is also seen that the selected permeation enhancers do not have significant deleterious effects on the skin structure. A cytotoxicity profile for each compound was established from cytotoxicity studies. Molecular dynamics simulation results provided a rationale for the experimental observations, introducing a mechanistic view of the action of the surfactants molecules upon lipid membranes.

Language: English

Type (Professor's evaluation): Scientific