Core I gene is overexpressed in Hurthle and non-Hurthle cell microfollicular adenomas and follicular carcinomas of the thyroid

• Type: Article in International Scientific Journal
• Date: 2004

Authors

Maximo, V (Author) Other; Preto, A (Author) Other; Crespo, A (Author) Other; Rocha, AS (Author) Other; Machado, JC (Author) FMUP; Soares, P (Author) FMUP; Sobrinho Simoes, M (Author) FMUP

Journal

Title: BMC Cancer

Vol. 4

ISSN: 1471-2407

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 5 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-000-B5F

DOI: 10.1186/1471-2407-4-12

Abstract (EN): Background: Most of the steps involved in the initiation and progression of Hurthle (oncocytic, oxyphilic) cell carcinomas of the thyroid remain unknown. Methods: Using differential display and semiquantitative RT-PCR we found, among other alterations, overexpression of the gene encoding the Core I subunit of the complex III of the mitochondrial respiratory chain in a follicular carcinoma composed of Hurthle cells. Results: Similar high levels of Core I gene expression were detected in nine follicular carcinomas (seven with Hurthle cell features), in seven microfollicular adenomas (one with Hurthle cell features) and in one micro/macrofollicular adenoma, in contrast to a lower/normal expression in nine papillary carcinomas (three with Hurthle cell features) and five macrofollicular adenomas (one of which displaying Hurthle cell features). No significative correlation was found between Core I overexpression and the proliferative activity of the lesions. Conclusions: We conclude that Core I overexpression in thyroid tumours is not associated with malignancy, Hurthle cells or proliferative activity. The pathogenetic mechanism linking Core I overexpression to the microfollicular pattern of growth of thyroid tumours remains to be clarified.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9