Molecular pathology of well-differentiated thyroid carcinomas

• Type: Another Publication in an International Scientific Journal
• Date: 2005

Authors

Sobrinho Simoes, M (Author) FMUP; Preto, A (Author) Other; Rocha, AS (Author) Other; Castro, P (Author) Other; Maximo, V (Author) Other; Fonseca, E (Author) Other; Soares, P (Author) FMUP

Journal

Title: Virchows Archiv

Vol. 447

Pages: 787-793

ISSN: 0945-6317

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 49 Citations

Scopus - 65 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-000-0VN

DOI: 10.1007/s00428-005-0065-5

Abstract (EN): The newly discovered molecular features of well-differentiated thyroid carcinomas derived from follicular cells are reviewed, within the frame of the 2004 WHO classification of thyroid tumours, under the following headings: "Follicular carcinoma", "Papillary carcinoma", "Follicular variant of papillary carcinoma" and "Hurthle cell tumours". A particular emphasis is put on the meaning of PAX8-PPAR gamma rearrangements, RAS and BRAF mutations, and deletions and mutations of mitochondrial genes and of nuclear genes encoding for mitochondrial enzymes, for thyroid tumorigenesis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7