The network of P-glycoprotein and microRNAs interactions

• Type: Another Publication in an International Scientific Journal
• Date: 2014

Authors

Vanessa Lopes Rodrigues (Author) Other; Hugo Seca (Author) Other; Diana Sousa (Author) Other; Emilia Sousa (Author) FFUP; Raquel T Lima (Author) Other; Helena Vasconcelos, MH (Author) FFUP

Journal

Title: International Journal of Cancer

Vol. 135

Pages: 253-263

ISSN: 0020-7136

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 47 Citations

Scopus - 52 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-008-PKB

DOI: 10.1002/ijc.28500

Abstract (EN): Overexpression of P-glycoprotein (P-gp) contributes to the multidrug resistance (MDR) phenotype found in many cancer cells. P-gp has been identified as a promising molecular target, although attempts to find successful therapies to counteract its function as a drug efflux pump have largely failed to date. Apart from its role in drug efflux, P-gp may have other cellular functions such as being involved in apoptosis, and is found in various locations in the cell. Its expression is highly regulated, namely by microRNAs (miRNAs or miRs). In addition, P-gp may regulate the expression of miRs in the cell. Furthermore, both P-gp and miRs may be found in microvesicles or exosomes and may be transported to neighboring, drug-sensitive cells. Here, we review this current issue together with recent evidence of this network of interactions between P-gp and miRs.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11