GRIM-19 function in cancer development

• Type: Another Publication in an International Scientific Journal
• Date: 2011

Authors

Severina Moreira (Author) Other; Marcelo Correia (Author) Other; Paula Soares (Author) FMUP; Valdemar Maximo (Author) FMUP

Journal

Title: Mitochondrion

Vol. 11

Pages: 693-699

ISSN: 1567-7249

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 30 Citations

Scopus - 31 Citations

Scientific classification

FOS: Natural sciences > Biological sciences

Other information

Authenticus ID: P-002-NAJ

DOI: 10.1016/j.mito.2011.05.011

Abstract (EN): Cancer development involves multiple genetic changes, which can occur in tumor suppressor genes and lead to loss of function in a recessive manner. Recent findings have identified a novel tumor suppressor gene named GRIM-19. Similar to what has been observed for other known tumor suppressor proteins such as p53, GRIM-19 gene mutations and loss of protein expression have been observed in several tumor types. In this review, we perform a detailed description on the current understanding of GRIM-19 function in carcinogenesis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7