2-Styrylchromones: Novel strong scavengers of reactive oxygen and nitrogen species

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Ana Gomes (Author) Other; Eduarda Fernandes (Author) FFUP; Artur M S Silva (Author) Other; Clementina M M Santos (Author) Other; Diana C G A Pinto (Author) Other; Jose A S Cavaleiro (Author) Other; Jose L F C Lima (Author) FFUP

Journal

Title: Bioorganic and Medicinal Chemistry

Vol. 15

Pages: 6027-6036

ISSN: 0968-0896

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 87 Citations

Scopus - 101 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-004-7GY

DOI: 10.1016/j.bmc.2007.06.046

Abstract (EN): 2-Styrylchromones are a small group of naturally occurring chromones, vinylogues of flavones (2-phenylchromones). Natural and synthetic 2-strylchromones have been tested in different biological systems, showing activities with potential therapeutic applications. In particular, the potential and hitherto understudied antioxidant behavior of these compounds has been raised as a matter of interest. Thus the present work consisted in the study of the in vitro scavenging activities for reactive oxygen species (ROS) and reactive nitroven species (RNS) of various 2-styrylchromone derivatives and structurally similar flavonoids. Some of the studied 2-styrylchromones proved to be extremely efficient scavengers of the different ROS and RNS, showing, in some cases, IC50S under 1 mu M. The hydroxylation pattern of 2-styrylchromones, especially in the B-ring but also in the A ring, modulates the activity of these compounds, the catecholic derivatives being the most effective scavengers. The styryl pattern also contributes to their observed outstanding antioxidant activity. In conclusion, the scavenging activities for ROS/RNS of 2-styrylehromone derivatives, here shown for the first time, provide novel and most promising compounds to be applied as antioxidants.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10