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ABAD: A Potential Therapeutic Target for A beta-Induced Mitochondrial Dysfunction in Alzheimer's Disease

Title
ABAD: A Potential Therapeutic Target for A beta-Induced Mitochondrial Dysfunction in Alzheimer's Disease
Type
Another Publication in an International Scientific Journal
Year
2009
Authors
Marques, AT
(Author)
Other
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Fernandes, PA
(Author)
FCUP
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Ramos, MJ
(Author)
FCUP
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Journal
Vol. 9
Pages: 1002-1008
ISSN: 1389-5575
Publisher: Bentham Science
Scientific classification
FOS: Medical and Health sciences > Basic medicine
Other information
Authenticus ID: P-003-HZF
Abstract (EN): Amyloid-beta-peptide (A beta)binding to mitochondrial A beta-binding alcohol dehydrogenase (ABAD) enzyme triggers a series of events leading to mitochondrial dysfunction characteristic of Alzheimer's disease (AD). Thus this interaction may represent a novel target for treatment strategy against AD. In this review we summarize current findings regarding the ABAD-A beta interaction, namely structural and biophysical data, available inhibitors and more recent data from proteomic studies.
Language: English
Type (Professor's evaluation): Scientific
Contact: mjramos@fc.up.pt
No. of pages: 7
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