Effects of recombinant granulocyte-colony stimulating factor administration during Mycobacterium avium infection in mice

• Type: Article in International Scientific Journal
• Date: 2001

Authors

Goncalves, AS (Author) Other; Appelberg, R (Author) ICBAS

Journal

Title: Clinical and Experimental Immunology

Vol. 124

Pages: 239-247

ISSN: 0009-9104

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 4 Citations

Pubmed / Medline

Scientific classification

FOS: Medical and Health sciences > Basic medicine

CORDIS: Health sciences > Medical sciences > Medicine > Infections

Other information

Authenticus ID: P-000-VKQ

DOI: 10.1046/j.1365-2249.2001.01552.x

Abstract (EN): Granulocyte colony-stimulating factor (G-CSF) administration in vivo has been shown to improve the defence mechanisms against infection by different microbes. Here we evaluated a possible protective role of this molecule in a mouse model of mycobacterial infection. The administration of recombinant G-CSF promoted an extensive blood neutrophilia but failed to improve the course of Mycobacterium avium infection in C57Bl/6 or beige mice. G-CSF administration also failed to improve the efficacy of a triple chemotherapeutic regimen (clarithromycin + ethambutol + rifabutin). G-CSF treatment did not protect interleukin-10 gene disrupted mice infected with M. avium. Spleen cells from infected mice treated with G-CSF had a decreased priming for antigen-specific production of interferon gamma compared to control infected mice. Our data do not substantiate previous reports on the protective activity of G-CSF in antimycobacterial immunity using mouse models.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9