Contribution of CD30/CD153 but not of CD27/CD70, CD134/OX40L, or CD137/4-1BBL to the optimal induction of protective immunity to Mycobacterium avium

• Type: Article in International Scientific Journal
• Date: 2004

Authors

Florido, M (Author) Other; Borges, M (Author) FFUP; Yagita, H (Author) Other; Appelberg, R (Author) ICBAS

Journal

Title: Journal of Leukocyte Biology

Vol. 76

Pages: 1039-1046

ISSN: 0741-5400

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 28 Citations

Scopus - 32 Citations

Pubmed / Medline

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

CORDIS: Health sciences > Medical sciences > Medicine > Infections

Other information

Authenticus ID: P-000-7Y1

DOI: 10.1189/jlb.1103572

Abstract (EN): A panel of monoclonal antibodies specific for CD27 ligand (CD70), CD30 ligand (CD153), CD134 ligand (OX40L), and CD137 ligand (4-1BBL) were screened in vivo for their ability to affect the control of Mycobacterium avium infection in C57B1/6 mice. Only the blocking of CD153 led to increased mycobacterial burdens. We then used CD30-deficient mice and found an increase in the proliferation of two strains of M. avium in these mice as compared with control animals. The increased mycobacterial growth was associated with decreased T cell expansion and reduced interferon-gamma (IFN-gamma) responses as a result of reduced polarization of the antigen-specific, IFN-gamma-producing T cells. At late times but not early in infection, the lymphoid cuff surrounding granulomas was depleted in the CD30-deficient animals. This report expands our knowledge about tumor necrosis factor superfamily members involved in the immune responses to mycobacterial infection by identifying CD30-CD153 interactions as required for optimal immune control of M. avium infection.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8