RET/PTC rearrangement is prevalent in follicular Hurthle cell carcinomas

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Margriet M de Vries (Author) Other; Ricardo Celestino (Author) Other; Patricia Castro (Author) FMUP; Catarina Eloy (Author) FMDUP; Valdemar Maximo (Author) FMUP; Jacqueline E van der Wal (Author) Other; John T M Plukker (Author) Other; Thera P Links (Author) Other; Robert M W Hofstra (Author) Other; Manuel Sobrinho Simoes (Author) FMUP; Paula Soares (Author) FMUP

Journal

Title: Histopathology

Vol. 61

Pages: 833-843

ISSN: 0309-0167

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 35 Citations

ISI Web of Science

Scopus - 46 Citations

Pubmed / Medline

Scientific classification

FOS: Medical and Health sciences > Basic medicine

CORDIS: Health sciences

Other information

Authenticus ID: P-002-42G

DOI: 10.1111/j.1365-2559.2012.04276.x

Abstract (EN): Aims: The molecular alterations underlying follicular Hurthle cell carcinomas (FHCCs) are largely unknown. In an attempt to clarify this issue, we analysed a series of Hurthle cell tumours for the presence of RET/PTC and PAX8/PPARG rearrangements and BRAF, HRAS and NRAS mutations. Methods and results: We investigated a series of 20 follicular Hurthle cell tumours [17 FHCCs and three follicular Hurthle cell adenomas (FHCAs)]. RET/PTC rearrangements were found in 33% of FHCAs and in 38% of FHCCs. All RET/PTC-positive FHCCs had a solid pattern of growth. PAX8/PPARG rearrangement was present in 27% of the FHCCs which displayed, in most cases, a follicular architecture. NRAS mutation was detected in one FHCC. An FHCC with a solid/microfollicular growth pattern scored positive for both RET/PTC and PAX8/PPARG rearrangement. Conclusions: Our study has shown a significant association between RET/PTC rearrangements and FHCCs with a solid growth pattern, thus raising the possibility of using tyrosine kinase inhibitors for the treatment of patients with FHCCs, which are often refractory to radioiodine treatment.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11