Structure function analysis of Leishmania sirtuin: An ensemble of In silico and biochemical studies

• Type: Article in International Scientific Journal
• Date: 2008

Authors

Rameshwar U Kadam (Author) Other; Joana Tavares (Author) FFUP; Kiran, VM (Author) Other; Anabela Cordeiro (Author) FFUP; Ali Ouaissi (Author) Other; Nilanjan Roy (Author) Other

Journal

Title: Chemical Biology and Drug Design

Vol. 71

Pages: 501-506

ISSN: 1747-0277

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 13 Citations

ISI Web of Science

Scopus - 16 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

CORDIS: Health sciences

Other information

Authenticus ID: P-003-ZJN

DOI: 10.1111/j.1747-0285.2008.00652.x

Resumo (PT): Novel anti-leishmanial target LmSir2 has few subtle but prudent structural differences in ligand binding and catalytic domain as compared to its human counterpart. In silico screening and validation followed by in vitro deacetylation and cell killing assays described herein give a proof of concept for development of strategies exploiting such minor differences for screening libraries of small molecules to identify selective inhibitors. <br> <br> Key words: leishmaniasis, nicotinamide and virtual screening, Sir2 <br> <a target="_blank" href="http://web.ebscohost.com/ehost/detail?vid=3&hid=106&sid=7436bf0e-ef17-48be-9c94-3f343d40468b%40sessionmgr109&bdata=JnNpdGU9ZWhvc3QtbGl2ZSZzY29wZT1zaXRl#db=a2h&AN=31573659#db=a2h&AN=31573659#db=a2h&AN=31573659"> Texto integral</a> <br> <br>

Abstract (EN): Novel anti-leishmanial target LmSir2 has few subtle but prudent structural differences in ligand binding and catalytic domain as compared to its human counterpart. In silico screening and validation followed by in vitro deacetylation and cell killing assays described herein give a proof of concept for development of strategies exploiting such minor differences for screening libraries of small molecules to identify selective inhibitors.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6