Improving the knowledge on Piper betle Targeted metabolite analysis and effect on acetylcholinesterase

• Type: Article in International Scientific Journal
• Date: 2010

Authors

Patricia Valentao (Author) FFUP; Rui F Goncalves (Author) Other; Cristovao Belo (Author) Other; de Pinho, PG (Author) FFUP; Paula B Andrade (Author) FFUP; Federico Ferreres (Author) Other

Journal

Title: Journal of Separation Science

Vol. 33 No. 20

Pages: 3168-3176

ISSN: 1615-9306

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 21 Citations

ISI Web of Science

Scopus - 23 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

CORDIS: Health sciences

Other information

Authenticus ID: P-003-2HF

DOI: 10.1002/jssc.201000429

Resumo (PT): Piper betle is a species growing in South East Asia, where its leaves are economically and medicinally important. To screen the highest possible number of volatile and semivolatile components, the leaves were subjected to headspace solid-phase microextraction, hydrodistillation and Soxhlet extraction, prior to analysis by GC/MS. Fifty compounds (identified by comparison with standard compounds or tentatively by National Institute of Standards and Technology database) were determined, 23 being described for the first time in this matrix. An aqueous extract was also analysed, in which only seven compounds were characterized. The organic acids' composition of this extract was determined by HPLC/UV and eight compounds are reported for the first time in P. betle. This extract also displayed acetylcholinesterase inhibitory capacity <br> <br> Keywords:Acetylcholinesterase inhibition;Organic acids;Piper betle;Volatile compounds <br> <a target="_blank" href="http://onlinelibrary.wiley.com/doi/10.1002/jssc.201000429/abstract">Texto integral</a> <br> <br>

Abstract (EN): Piper betle is a species growing in South East Asia where its leaves are economically and medicinally important To screen the highest possible number of volatile and semivolatile components the leaves were subjected to headspace solid phase microextraction hydro distillation and Soxhlet extraction prior to analysis by GC/MS Fifty compounds (identified by comparison with standard compounds or tentatively by National Institute of Standards and Technology database) were determined 23 being described for the first time in this matrix An aqueous extract was also analysed in which only seven compounds were characterized The organic acids composition of this extract was determined by HPLC/UV and eight compounds are reported for the first time in P betle This extract also displayed acetylcholinesterase inhibitory capacity

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9