Numerical study of the fractionation of two macromolecules with similar MW in a hybrid cell with electrically charged membranes

• Type: Article in International Scientific Journal
• Date: 2013

Authors

S. I. S. Pinto (Author) FEUP; J. M. Miranda (Author) FEUP; J. B. L. M. Campos (Author) FEUP

Journal

Title: Desalination

Vol. 317 No. MAY 15 2013

Pages: 95-107

ISSN: 0011-9164

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Scientific classification

CORDIS: Technological sciences > Engineering > Chemical engineering

FOS: Engineering and technology > Chemical engineering

Associated Projects

Células híbridas de separação por membranas - Células híbridas de separação por membranas

Other information

Authenticus ID: P-005-0QA

DOI: 10.1016/j.desal.2013.03.006

Abstract (EN): In solute fractionation by ultrafiltration, concentration polarization increases the transmission of the components and, consequently, decreases the separation selectivity. Several techniques have been explored to increase the selectivity. Hybrid membrane cell is a concept that has been developed having in mind this purpose. Membrane-solute electric interactions determine, in a great part, the fractionation selectivity, when macromolecules to be separated have similar molecular weight, generally macromolecules difficult to separate by ultrafiltration. The purpose of the present work is to explore, by numerical simulation, the potential of a hybrid membrane cell composed by: 1-membranes electrically charged and impermeable to the solutes; and 2-membranes electrically charged and selective, alternating along the cell, to fractionate two macromolecules with similar molecular weight (e.g., Iysozyme/Dextran-T10). The apparent selectivity of the fractionation using a hybrid cell with electrically charged membranes is significantly higher (2.4), relatively to using a conventional cell (1.1). While lysozyme is repelled by electric interactions, Dextran-T10 accumulates along the impermeable membranes surface and is removed through the selective membranes located downstream. In conclusion, the hybrid cell with electrically charged and selective membranes is an advantageous method to separate two macromolecules with similar MW, provided they have opposite electric charges.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13