Bis-chalcones: A review of synthetic methodologies and anti-inflammatory effects

• Type: Another Publication in an International Scientific Journal
• Date: 2023

Authors

Pereira, R (Author) Other; Silva, AMS (Author) Other; Ribeiro, D (Author) Other; Silva, VLM (Author) Other; Eduarda Fernandes (Author) FFUP

Journal

Title: European Journal of Medicinal Chemistry

Vol. 252

ISSN: 0223-5234

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00Y-68E

DOI: 10.1016/j.ejmech.2023.115280

Abstract (EN): Chalcones are bioactive molecules of natural and synthetic sources, whose physicochemical properties, reac-tivity, and biological activities are well-known among the scientific community. However, there are many molecules strictly related to chalcones with significantly less recognition like bis-chalcones. Several studies indicated that bis-chalcones have advantages over chalcones in specific bioactivities like anti-inflammatory activity.This review article describes the chemical structure and chemical properties of bis-chalcones, as well as the methods reported in the literature for the synthesis of these compounds highlighting the most recent de-velopments. Finally, the anti-inflammatory activity of bis-chalcones is described, emphasizing the active struc-tures found in literature and their mechanisms of action.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 22