Delayed Extensive Local Reaction to the mRNA-1273 Vaccine against SARS-CoV-2: A Case Report

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Ferreira-da-Silva, R (Author) FMUP; Ribeiro-Vaz, I (Author) FMUP; Silva, AM (Author) FMUP; Nunes, F (Author) Other; Morato, M (Author) Other; Polonia, J (Author) FMUP; Guedes, P (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: JOURNAL OF PHARMACOLOGY & PHARMACOTHERAPEUTICS

Vol. 13

Pages: 401-403

ISSN: 0976-500X

Indexing

ISI Web of Knowledge - 0 Citations

Other information

Authenticus ID: P-00X-SVH

DOI: 10.1177/0976500x221147748

Abstract (EN): In response to the COVID-19 pandemic, two mRNA vaccines (Comirnaty and Spikevax) received emergency use authorization from the European Medicines Agency. This case report aimed to report a delayed adverse reaction to the mRNA-1273 vaccine against COVID-19 from a Portuguese vaccination center.A case report was performed with medical observation and reported to the Portuguese Pharmacovigilance System, then investigated based on the WHO-UMC Causality Categories. A 66-year-old female patient with a clinical history of dyslipidemia, essential arterial hypertension, obesity, multinodular goitre and cholecystectomy, who presented delayed large cutaneous hypersensitivity reaction following Spikevax COVID-19 mRNA (mRNA-1273) vaccine administration.Our clinical findings (time and clinical appearance), along with evidence of previously reported histological findings, are strongly suggestive of T-cell-mediated hypersensitivity. There is no contraindication to the inoculation of subsequent doses in patients developing these clinical conditions, and vaccination should continue to be strongly encouraged.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3