Renin-Angiotensin System in Lung Tumor and Microenvironment Interactions

• Type: Another Publication in an International Scientific Journal
• Date: 2020

Authors

Catarata, MJ (Author) Other; Ribeiro, R (Author) Other; Oliveira, MJ (Author) ICBAS; Robalo Cordeiro, CR (Author) Other; Rui Medeiros (Author) ICBAS

Journal

Title: Cancers

Vol. 12

Pages: 1-24

ISSN: 2072-6694

Publisher: MDPI

Indexing

ISI Web of Knowledge - 34 Citations

Scopus - 34 Citations

Other information

Authenticus ID: P-00S-9HZ

DOI: 10.3390/cancers12061457

Abstract (EN): The mechanistic involvement of the renin-angiotensin system (RAS) reaches beyond cardiovascular physiopathology. Recent knowledge pinpoints a pleiotropic role for this system, particularly in the lung, and mainly through locally regulated alternative molecules and secondary pathways. Angiotensin peptides play a role in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. This manuscript reviews the literature supporting a role for the renin-angiotensin system in the lung tumor microenvironment and discusses whether blockade of this pathway in clinical settings may serve as an adjuvant therapy in lung cancer.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 25