Towards Drug Repurposing in Cancer Cachexia: Potential Targets and Candidates

• Type: Another Publication in an International Scientific Journal
• Date: 2021

Authors

Santos, JMO (Author) Other; Costa, AC (Author) Other; Dias, TR (Author) Other; Satari, S (Author) Other; Rui Medeiros (Author) ICBAS; da Costa, RMG (Author) Other; Medeiros, R (Author) Other

Journal

Title: Pharmaceuticals

Vol. 12

Final page: 1084

ISSN: 1424-8247

Publisher: MDPI

Indexing

ISI Web of Knowledge - 7 Citations

Scopus - 8 Citations

Other information

Authenticus ID: P-00V-P2X

DOI: 10.3390/ph14111084

Abstract (EN): As a multifactorial and multiorgan syndrome, cancer cachexia is associated with decreased tolerance to antitumor treatments and increased morbidity and mortality rates. The current approaches for the treatment of this syndrome are not always effective and well established. Drug repurposing or repositioning consists of the investigation of pharmacological components that are already available or in clinical trials for certain diseases and explores if they can be used for new indications. Its advantages comparing to de novo drugs development are the reduced amount of time spent and costs. In this paper, we selected drugs already available or in clinical trials for non-cachexia indications and that are related to the pathways and molecular components involved in the different phenotypes of cancer cachexia syndrome. Thus, we introduce known drugs as possible candidates for drug repurposing in the treatment of cancer-induced cachexia.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 27