Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium

• Type: Article in International Scientific Journal
• Date: 2023

Authors

Collatuzzo, G (Author) Other; Negri, E (Author) Other; Pelucchi, C (Author) Other; Bonzi, R (Author) Other; Turati, F (Author) Other; Rabkin, CS (Author) Other; Liao, LM (Author) Other; Sinha, R (Author) Other; Palli, D (Author) Other; Ferraroni, M (Author) Other; Lopez Carrillo, L (Author) Other; Lunet N (Author) FMUP; Morais, S (Author) Other; Albanes, D (Author) Other; Weinstein, SJ (Author) Other; Parisi, D (Author) Other; Zaridze, D (Author) Other; Maximovitch, D (Author) Other; Dierssen Sotos, T (Author) Other; Jimenez Moleon, JJ (Author) Other; Vioque, J (Author) Other; de la Hera, MG (Author) Other; Curado, MP (Author) Other; Dias Neto, E (Author) Other; Hernandez Ramirez, RU (Author) Other; Lopez Cervantes, M (Author) Other; Ward, MH (Author) Other; Tsugane, S (Author) Other; Hidaka, A (Author) Other; Lagiou, A (Author) Other; Lagiou, P (Author) Other; Zhang, ZF (Author) Other; Trichopoulou, A (Author) Other; Karakatsani, A (Author) Other; Camargo, MC (Author) Other; La Vecchia, C (Author) Other; Boffetta, P (Author) Other

Journal

Title: Nutrients

Final page: 1877

ISSN: 2072-6643

Publisher: MDPI

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00Y-8RR

DOI: 10.3390/nu15081877

Abstract (EN): Background: Yoghurt can modify gastrointestinal disease risk, possibly acting on gut microbiota. Our study aimed at exploring the under-investigated association between yoghurt and gastric cancer (GC). Methods: We pooled data from 16 studies from the Stomach Cancer Pooling (StoP) Project. Total yoghurt intake was derived from food frequency questionnaires. We calculated study-specific odds ratios (ORs) of GC and the corresponding 95% confidence intervals (CIs) for increasing categories of yoghurt consumption using univariate and multivariable unconditional logistic regression models. A two-stage analysis, with a meta-analysis of the pooled adjusted data, was conducted. Results: The analysis included 6278 GC cases and 14,181 controls, including 1179 cardia and 3463 non-cardia, 1191 diffuse and 1717 intestinal cases. The overall meta-analysis revealed no association between increasing portions of yoghurt intake (continuous) and GC (OR = 0.98, 95% CI = 0.94-1.02). When restricting to cohort studies, a borderline inverse relationship was found (OR = 0.93, 95% CI = 0.88-0.99). The adjusted and unadjusted OR were 0.92 (95% CI = 0.85-0.99) and 0.78 (95% CI = 0.73-0.84) for any vs. no yoghurt consumption and GC risk. The OR for 1 category of increase in yoghurt intake was 0.96 (95% CI = 0.91-1.02) for cardia, 1.03 (95% CI = 1.00-1.07) for non-cardia, 1.12 (95% CI = 1.07-1.19) for diffuse and 1.02 (95% CI = 0.97-1.06) for intestinal GC. No effect was seen within hospital-based and population-based studies, nor in men or women. Conclusions: We found no association between yoghurt and GC in the main adjusted models, despite sensitivity analyses suggesting a protective effect. Additional studies should further address this association.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13