Liquid Chromatography on the Different Methods for the Determination of Lipophilicity: An Essential Analytical Tool in Medicinal Chemistry

• Type: Another Publication in an International Scientific Journal
• Date: 2022

Authors

Jose X Soares (Author) FFUP; Santos, A (Author) Other; Carla Fernandes (Author) FFUP; Pinto, MMM (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: Chemosensors

Vol. 10

Final page: 340

ISSN: 2227-9040

Indexing

ISI Web of Knowledge - 0 Citations

Scopus

Other information

Authenticus ID: P-00X-536

DOI: 10.3390/chemosensors10080340

Abstract (EN): Lipophilicity is one of many parameters involved in the biological activity of drugs, as it affects their pharmacokinetic and pharmacodynamic behavior. Generally, lipophilicity is assessed by the partition coefficient of a compound between a nonpolar phase (n-octanol) and an aqueous phase (water), expressed as P (partition coefficient) or as its decimal logarithm (Log P). The gold standard method for the experimental determination of Log P is the shake-flask method. In this context, chromatographic methods enable the direct and simple quantification of the partitioned compound between the two phases. This review discusses the use of liquid chromatography (LC) for direct and indirect determination of lipophilicity. Beyond the classical isotropic log P determination, methods for assessing anisotropic lipophilicity are also reviewed. Several examples are discussed that highlight the versatility of LC technique and current trends. The last section of this review focuses on a case study describing an experience of our group and emphasizing the dual role of LC in determining Log P.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 41