Different Ability of Multidrug-Resistant and -Sensitive Counterpart Cells to Release and Capture Extracellular Vesicles

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Sousa, D (Author) Other; Lima, RT (Author) Other; Lopes Rodrigues, V (Author) Other; Gonzalez, E (Author) Other; Royo, F (Author) Other; Xavier, CPR (Author) Other; Falcon Perez, JM (Author) Other; Helena Vasconcelos, MH (Author) FFUP

Journal

Title: Cells

Vol. 14

Final page: 2886

ISSN: 2073-4409

Publisher: MDPI

Indexing

ISI Web of Knowledge - 1 Citation

Scopus - 1 Citation

Other information

Authenticus ID: P-00V-M9W

DOI: 10.3390/cells10112886

Abstract (EN): Cancer multidrug resistance (MDR) is one of the main challenges for cancer treatment efficacy. MDR is a phenomenon by which tumor cells become resistant to several unrelated drugs. Some studies have previously described the important role of extracellular vesicles (EVs) in the dissemination of a MDR phenotype. EVs' cargo may include different players of MDR, such as microRNAS and drug-efflux pumps, which may be transferred from donor MDR cells to recipient drug-sensitive counterparts. The present work aimed to: (i) compare the ability of drug-sensitive and their MDR counterpart cells to release and capture EVs and (ii) study and relate those differences with possible distinct fate of the endocytic pathway in these counterpart cells. Our results showed that MDR cells released more EVs than their drug-sensitive counterparts and also that the drug-sensitive cells captured more EVs than their MDR counterparts. This difference in the release and capture of EVs may be associated with differences in the endocytic pathway between drug-sensitive and MDR cells. Importantly, manipulation of the recycling pathway influenced the response of drug-sensitive cells to doxorubicin treatment.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 19