Trends in Atopic Dermatitis-From Standard Pharmacotherapy to Novel Drug Delivery Systems

• Type: Another Publication in an International Scientific Journal
• Date: 2019

Authors

Souto, EB (Author) Other; Dias Ferreira, J (Author) Other; Oliveira, J (Author) Other; Sanchez Lopez, E (Author) Other; Lopez Machado, A (Author) Other; Espina, M (Author) Other; Garcia, ML (Author) Other; Souto, SB (Author) Other; Martins Gomes, C (Author) Other; Silva, AM (Author) Other

Journal

Title: International Journal Of Molecular Sciences

Vol. 20

Final page: 5659

ISSN: 1661-6596

Publisher: MDPI

Indexing

ISI Web of Knowledge - 26 Citations

Scopus - 33 Citations

Scientific classification

CORDIS: Health sciences

Other information

Authenticus ID: P-00R-8KH

DOI: 10.3390/ijms20225659

Abstract (EN): Atopic dermatitis (AD) is a predominant and deteriorating chronic inflammation of the skin, categorized by robust burning and eczematous lacerations in diverse portions of the body. AD affects about 20% of both offspring and adults worldwide. The pathophysiology of AD combines environmental, hereditary, and immunological aspects, together with skin barrier dysfunction. The procedures used to prevent the disease are the everyday usage of creams to support the restoration of the epidermal barrier. The classical treatments include the use of topical corticosteroids as a first-line therapy, but also calcineurin inhibitors, antihistamines, antibiotics, phototherapy, and also immunosuppressant drugs in severe cases of AD. Topical drug delivery to deeper skin layers is a difficult task due to the skin anatomic barrier, which limits deeper penetration of drugs. Groundbreaking drug delivery systems, based on nanoparticles (NPs), have received much attention due to their ability to improve solubility, bioavailability, diffusion, targeting to specific types of cells, and limiting the secondary effects of the drugs employed in the treatment of AD. Even so, additional studies are still required to recognize the toxicological characteristics and long-term safety of NPs. This review discusses the current classical pharmacotherapy of AD against new nanoparticle skin delivery systems and their toxicologic risks.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 17