The Therapeutic Potential of Apigenin

• Type: Another Publication in an International Scientific Journal
• Date: 2019

Authors

Salehi, B (Author) Other; Venditti, A (Author) Other; Sharifi Rad, M (Author) Other; Kregiel, D (Author) Other; Sharifi Rad, J (Author) Other; Durazzo, A (Author) Other; Lucarini, M (Author) Other; Santini, A (Author) Other; Souto, EB (Author) Other; Novellino, E (Author) Other; Antolak, H (Author) Other; Azzini, E (Author) Other; Setzer, WN (Author) Other; Martins, N (Author) Other

Journal

Title: International Journal Of Molecular Sciences

Vol. 20

Final page: 1305

ISSN: 1661-6596

Publisher: MDPI

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 182 Citations

Scientific classification

CORDIS: Health sciences

Other information

Authenticus ID: P-00Q-C1A

DOI: 10.3390/ijms20061305

Abstract (EN): Several plant bioactive compounds have exhibited functional activities that suggest they could play a remarkable role in preventing a wide range of chronic diseases. The largest group of naturally-occurring polyphenols are the flavonoids, including apigenin. The present work is an updated overview of apigenin, focusing on its health-promoting effects/therapeutic functions and, in particular, results of in vivo research. In addition to an introduction to its chemistry, nutraceutical features have also been described. The main key findings from in vivo research, including animal models and human studies, are summarized. The beneficial indications are reported and discussed in detail, including effects in diabetes, amnesia and Alzheimer's disease, depression and insomnia, cancer, etc. Finally, data on flavonoids from the main public databases are gathered to highlight the apigenin's key role in dietary assessment and in the evaluation of a formulated diet, to determine exposure and to investigate its health effects in vivo.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 26