Current advances in the development of novel polymeric nanoparticles for the treatment of neurodegenerative diseases

• Type: Another Publication in an International Scientific Journal
• Date: 2020

Authors

Cano, A (Author) Other; Sanchez Lopez, E (Author) Other; Ettcheto, M (Author) Other; Lopez Machado, A (Author) Other; Espina, M (Author) Other; Souto, EB (Author) Other; Galindo, R (Author) Other; Camins, A (Author) Other; Garcia, ML (Author) Other; Turowski, P (Author) Other

Journal

Title: Nanomedicine

Vol. 15 No. 6

Pages: 1239-1261

ISSN: 1743-5889

Publisher: Future Medicine Ltd.

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 11 Citations

Scientific classification

CORDIS: Health sciences

Other information

Authenticus ID: P-00S-9NQ

DOI: 10.2217/nnm-2019-0443

Abstract (EN): Effective intervention is essential to combat the coming epidemic of neurodegenerative (ND) diseases. Nanomedicine can overcome restrictions of CNS delivery imposed by the blood-brain barrier, and thus be instrumental in preclinical discovery and therapeutic intervention of ND diseases. Polymeric nanoparticles (PNPs) have shown great potential and versatility to encapsulate several compounds simultaneously in controlled drug-delivery systems and target them to the deepest brain regions. Here, we critically review recent advances in the development of drugs incorporated into PNPs and summarize the molecular changes and functional effects achieved in preclinical models of the most common ND disorders. We also briefly discuss the many challenges remaining to translate these findings and technological advances successfully to current clinical settings.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 23