Pro-inflammatory effects of silver nanoparticles in the intestine

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Sousa, A (Author) Other; Bradshaw, TD (Author) Other; Ribeiro, D (Author) Other; Eduarda Fernandes (Author) FFUP; Freitas, M (Author) Other

Journal

Title: Archives of Toxicology

ISSN: 0340-5761

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00W-A1X

DOI: 10.1007/s00204-022-03270-w

Abstract (EN): Nanotechnology is a promising technology of the twenty-first century, being a rapidly evolving field of research and industrial innovation widely applied in our everyday life. Silver nanoparticles (AgNP) are considered the most commercialized nanosystems worldwide, being applied in diverse sectors, from medicine to the food industry. Considering their unique physical, chemical and biological properties, AgNP have gained access into our daily life, with an exponential use in food industry, leading to an increased inevitable human oral exposure. With the growing use of AgNP, several concerns have been raised, in recent years, about their potential hazards to human health, more precisely their pro-inflammatory effects within the gastrointestinal system. Therefore a review of the literature has been undertaken to understand the pro-inflammatory potential of AgNP, after human oral exposure, in the intestine. Despite the paucity of information reported in the literature about this issue, existing studies indicate that AgNP exert a pro-inflammatory action, through generation of oxidative stress, accompanied by mitochondrial dysfunction, interference with transcription factors and production of cytokines. However, further studies are needed to elucidate the mechanistic pathways and molecular targets involved in the intestinal pro-inflammatory effects of AgNP.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 21