Optimizing SLN and NLC by 2(2) full factorial design: Effect of homogenization technique

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Severino, P (Author) Other; Santana, MHA (Author) Other; Souto, EB (Author) Other

Journal

Title: Materials Science and Engineering C

Vol. 32

Pages: 1375-1379

ISSN: 0928-4931

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 33 Citations

Scopus - 61 Citations

Other information

Authenticus ID: P-002-7QW

DOI: 10.1016/j.msec.2012.04.017

Abstract (EN): Solid lipid nanoparticles (SLN) and nanostructured lipid carrier (NLC) have been employed in pharmaceutics and biomedical formulations. The present study focuses on the optimization of the production process of SLN and NLC by High Shear Homogenization (HSH) and High Pressure Homogenization (HPH). To build up the surface response charts, a 2(2) full factorial design based on 2 independent variables was used to obtain an optimized formulation. The effects of the production process on the mean particle size, polydispersity index (PI) and zeta potential (ZP) were investigated. Optimized SLN were produced applying 20,000 rpm HSH and 500 bar HPH pressure and NLC process 15,000 rpm HSH and 700 bar HPH pressure, respectively. This factorial design study has proven to be a useful tool in optimizing SLN (similar to 100 nm) and NLC (similar to 300 nm) formulations. The present results highlight the benefit of applying statistical designs in the preparation of lipid nanoparticles.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5