Engineering of PKS Megaenzymes-A Promising Way to Biosynthesize High-Value Active Molecules

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Neves, RPP (Author) FCUP; Ferreira, P (Author) Other; Medina, FE (Author) Other; Paiva, P (Author) Other; Sousa, JPM (Author) Other; Viegas, MF (Author) Other; Pedro A Fernandes (Author) FCUP; Ramos, MJ (Author) FCUP

Journal

Title: Topics in Catalysis

Vol. 65

Pages: 544-562

ISSN: 1022-5528

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 1 Citation

Other information

Authenticus ID: P-00V-BPZ

DOI: 10.1007/s11244-021-01490-5

Abstract (EN): Polyketide synthases (PKS) produce polyketides, a large group of secondary metabolites produced in bacteria, fungi, plants and certain animal families. PKSs have a huge potential to biosynthesize high-value active pharmaceuticals, agrochemicals, biofuels and industrial chemicals, among others. Additionally, they present ideal opportunities to engineer new polyketides, and the latter chemical novelty can result in even better, or at least alternative, active molecules to the existing ones. We present the structure, catalysis and altogether machinery of the PKS, as well as their enzyme engineering and applications in biotechnology. We also briefly discuss the current progress on the study of PKSs by computational chemists, and the fact that PKS reactivity and catalysis remain, presently, almost open fields for the computational chemist to explore.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 19