Microencapsulation of Enriched Extracts of Two Satureja Species by Spray Drying, Evaluation of the Controlled Release Mechanism and Cytotoxicity

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Fathi, F (Author) Other; Ebrahimi, SN (Author) Other; Pereira, DM (Author) Other; Berta Nogueiro Estevinho (Author) FEUP; Fernando Rocha (Author) FEUP

Journal

The Journal is awaiting validation by the Administrative Services.

Title: PHARMACEUTICAL SCIENCES

Vol. 28

Pages: 145-155

ISSN: 1735-403X

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Associated Projects

MicroDelivery - Desenvolvimento de sistemas funcionais de libertação controlada por microencapsulação de compostos ativos e naturais, com interesse terapêutico, nutricional e tecnológico

Other information

Authenticus ID: P-00W-9Q4

DOI: 10.34172/ps.2021.54

Abstract (EN): Background: Phenolic compounds are one of the main groups of secondary metabolites responsible for multiple biological and pharmacological properties that play a vital role in improving human health quality. Encapsulation by spray dryer creates protection toward the phenolic compounds as an efficient way for increasing product performance. Methods: The phenolic compounds of Satureja khuzistanica Jamzad (SKH) and S. rechingeri Jamzad (SRH) were enriched based on adsorbent resin column chromatography and the enrichment index was confirmed by HPLC- UV analysis. Gum Arabic, carboxylated chitosan, and pectin with the optimum percentage of 1% w/w used to encapsulate SKH and SRH by the spray drying technique. Results: Encapsulation yield was 38.18 - 59.00 %, particle size ranged 2.278 - 4.689 tun, and release time was between 4.08 - 82.08 min. The gum Arabic-based capsules showed the fastest and pectin-based revealed the slowest release time. The best kinetic model explained a release mechanism was Korsmeyer model. Anomalous transport was observed from all formulas except SKH-gum Arabic (case-I transport), SKH-pectin, and SRH-carboxylated-chitosan (super case-II transport). The cytotoxic activity of encapsulate SKH's revealed reducing the viability of AGS evaluated by the MTT compared with SRH's. Conclusion: Encapsulation by spray drying has proven to be a promising technique to improve the bioavailability, release time, and mechanism of functional polyphenolic compounds as medicines, food supplements, and food additives.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11