Highlighting Immune System and Stress in Major Depressive Disorder, Parkinson's, and Alzheimer's Diseases, with a Connection with Serotonin

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Correia, AS (Author) Other; Armando Cardoso (Author) FMUP; Nuno Vale (Author) FMUP

Journal

Title: International Journal Of Molecular Sciences

Vol. 22

Final page: 8525

ISSN: 1661-6596

Publisher: MDPI

Indexing

ISI Web of Knowledge - 5 Citations

Other information

Authenticus ID: P-00V-85Y

DOI: 10.3390/ijms22168525

Abstract (EN): There is recognition that both stress and immune responses are important factors in a variety of neurological disorders. Moreover, there is an important role of several neurotransmitters that connect these factors to several neurological diseases, with a special focus in this paper on serotonin. Accordingly, it is known that imbalances in stressors can promote a variety of neuropsychiatric or neurodegenerative pathologies. Here, we discuss some facts that link major depressive disorder, Alzheimer's, and Parkinson's to the stress and immune responses, as well as the connection between these responses and serotonergic signaling. These are important topics of investigation which may lead to new or better treatments, improving the life quality of patients that suffer from these conditions.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 18