Neuropeptide Y inhibits the trigeminovascular pathway through NPY Y-1 receptor: implications for migraine

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Oliveira, MM (Author) Other; Akerman, S (Author) Other; Isaura Tavares (Author) FMUP; Goadsby, PJ (Author) Other

Journal

Title: Pain

Vol. 157

Pages: 1666-1673

ISSN: 0304-3959

Publisher: Wolters Kluwer Health

Indexing

ISI Web of Knowledge - 30 Citations

Scopus - 34 Citations

Other information

Authenticus ID: P-00K-P6S

DOI: 10.1097/j.pain.0000000000000571

Abstract (EN): Migraine is a painful neurologic disorder with premonitory symptomatology that can include disturbed appetite. Migraine pathophysiology involves abnormal activation of trigeminocervical complex (TCC) neurons. Neuropeptide Y (NPY) is synthesized in the brain and is involved in pain modulation. NPY receptors are present in trigeminal ganglia and trigeminal nucleus caudalis suggesting a role in migraine pathophysiology. The present study aimed to determine the effect of systemic administration of NPY on TCC neuronal activity in response to dural nociceptive trigeminovascular activation. We performed in vivo electrophysiology in anesthetized rats, administered NPY (10, 30, and 100 mu g.kg(-1) ), and investigated the receptors involved by studying NPY Y-1 (30 mu g.kg(-1)), Y-2 (30 mu g.kg(-1)), and Y-5 receptor agonists (100 mu g.kg(-1)), and NPY Y-1 receptor antagonist (30 mu g.kg(-1)). NPY (30 and 100 mu g.kg(-1)) significantly reduced TCC neuronal firing in response to dural-evoked trigeminovascular activation, but only NPY (30 mu g.kg(-1)) significantly reduced spontaneous trigeminal firing. NPY Y-1 receptor agonist also significantly reduced dural-evoked and spontaneous TCC neuronal firing. NPY (10 mu g.kg(-1)), NPY Y-2, and Y-5 receptor agonists, and the NPY Y-1 receptor antagonist had no significant effects on nociceptive dural-evoked neuronal firing in the TCC or spontaneous trigeminal firing. This study demonstrates that NPY dose dependently inhibits dural-evoked trigeminal activity, through NPY Y-1 receptor activation, indicating antinociceptive actions of NPY in a migraine animal model. Based on the role of NPY in appetite regulation, it is possible that disruption of the NPY system might explain changes of appetite in migraineurs.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8