Prediagnosis lifestyle exposures and survival of patients with gastric cancer: systematic review and meta-analysis

• Type: Another Publication in an International Scientific Journal
• Date: 2012

Authors

Ferronha, I (Author) Other; Bastos, A (Author) Other; Lunet N (Author) FMUP

Journal

Title: European Journal of Cancer Prevention

Vol. 21

Pages: 449-452

ISSN: 0959-8278

Publisher: Wolters Kluwer Health

Indexing

ISI Web of Knowledge - 19 Citations

Scopus - 20 Citations

Other information

Authenticus ID: P-002-6N0

DOI: 10.1097/cej.0b013e32834fdb1b

Abstract (EN): The relation between lifestyles and gastric cancer has been investigated thoroughly; however few studies have addressed the impact of these exposures on prognosis. Therefore, we quantified the association between prediagnosis smoking, alcohol intake and other dietary exposures and the survival of gastric cancer patients through a systematic review and meta-analysis. We searched Pubmed and EMBASE up to April 2011 and computed summary hazard ratio estimates and respective 95% confidence intervals (95% CIs) through a random-effects meta-analysis (DerSimonian and Laird). Heterogeneity was quantified using the I-2 statistic. Seven articles, providing data from 6856 cases evaluated in seven countries (Canada, Japan, Italy, USA, Korea, Iran and Sweden), were eligible for meta-analysis. The summary hazard ratio was 1.08 (95% CI: 0.90-1.30) for smoking (current vs. never smokers, seven studies; I-2 = 56.2%) and 1.13 (95% CI: 1.00-1.28) for alcohol consumption (drinkers vs. nondrinkers, five studies; I-2 = 13.2%). Only two studies assessed the effect of other dietary factors. This study summarizes the best evidence available on the relation between prediagnosis lifestyles and the survival of gastric cancer patients. Alcohol drinkers have lower survival, but results on the effect of smoking lack consistency and there is almost no information on the effects of dietary factors. European Journal of Cancer Prevention 21:449-452 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4