Association between nonalcoholic fatty liver disease and cardiac function and structure-a meta-analysis

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Borges Canha, M (Author) FMUP; Neves, JS (Author) FMUP; Lib?nio, D (Author) FMUP; Von Hafe, M (Author) Other; Vale, C (Author) Other; Ara?jo Martins, M (Author) Other; Leite, AR (Author) Other; Pimentel Nunes, P (Author) Other; Carvalho, Davide (Author) FMUP; Leite-Moreira AF (Author) FMUP

Journal

Title: Endocrine

Vol. 66

Pages: 467-476

ISSN: 0969-711X

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 23 Citations

Scopus - 22 Citations

Other information

Authenticus ID: P-00R-27W

DOI: 10.1007/s12020-019-02070-0

Abstract (EN): Purpose Nonalcoholic fatty liver disease is increasingly recognized as the hepatic counterpart of metabolic syndrome. It is hypothesized that structural and functional cardiac changes may be associated with this metabolic disease. We aimed to gather the existing information on the association of nonalcoholic fatty liver disease with cardiac alterations, and to evaluate a possible correlation between them. Methods Systematic review of Medline searching results for original articles studying NAFLD and cardiac parameters until August 2018. A meta-analysis was conducted to each parameter of cardiac structure and function selected, using Review Manager 5.3 software. This study was conducted according to preferred reporting items for systematic reviews and meta-analysis (PRISMA). Results A total of 16 studies met the eligibility criteria and were included in the meta-analysis. There was a significant association between nonalcoholic fatty liver disease and (1) higher left ventricle mass and ratios between left ventricle mass and both height and body surface area; (2) higher LVEDD; (3) higher left atrium diameter and ratio between left atrial volume and body surface area; (4) higher posterior wall and septum thickness; (5) lower E/A wave ratio; (6) higher E/E' ratio; (7) longer deceleration time and (8) longer relaxation time. Conclusion NAFLD associates with adverse structural alterations and cardiac dysfunction. Our results highlight the importance of identifying NAFLD in patients with metabolic dysfunction as this may represent an additional contributor to cardiovascular risk.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10