Monoamine oxidase inhibitors: Ten years of docking studies

• Type: Another Publication in an International Scientific Journal
• Date: 2012

Authors

Ferino, G (Author) Other; Vilar, S (Author) Other; Matos, MJ (Author) Other; Uriarte, E (Author) Other; Cadoni, E (Author) Other

Journal

Title: Current Topics in Medicinal Chemistry

Vol. 12

Pages: 2145-2162

ISSN: 1568-0266

Publisher: Bentham

Indexing

Scopus - 28 Citations

Other information

Authenticus ID: P-00R-0MY

DOI: 10.2174/156802612805220048

Abstract (EN): The number of papers dealing with the structure-based drug design is continuously growing, which demonstrates the importance of such tools in medicinal chemistry. In the current paper, the published literature concerning the use of the ligand-protein docking methodologies in the study of the monoamine oxidase (MAO) enzymes was reviewed. Ten years of studies aimed at developing new compounds active as MAO inhibitors (MAOIs) were covered. The literature regarding thiazole, caffeine, pyrazole, chromone, indeno-pyridazin, P-carboline, indole, coumarin, anilide and amphetamine derivatives, was discussed in some detail. It is apparent that, through this computational approach, more selective and potent molecules can be proposed as inhibitors by applying precise modifications on the basic scaffold. © 2012 Bentham Science Publishers.

Language: English

Type (Professor's evaluation): Scientific