Looking for new targets: Simple coumarins as antibacterial agents

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Matos, MJ (Author) Other; Vazquez Rodriguez, S (Author) Other; Santana, L (Author) Other; Uriarte, E (Author) Other; Fuentes Edfuf, C (Author) Other; Santos, Y (Author) Other; Muñoz Crego, A (Author) Other

Journal

Title: Medicinal Chemistry

Vol. 8

Pages: 1140-1145

ISSN: 1573-4064

Publisher: Bentham

Indexing

Scopus - 54 Citations

Other information

Authenticus ID: P-00R-0MT

DOI: 10.2174/1573406411208061140

Abstract (EN): The dramatic worldwide increase of dangerous infections by resistant and multi-resistant microbes makes the search of new molecules and new chemical entities an important topic in Medicinal Chemistry. As the ideal drug candidate has not been attained, an intensive search for new and innovative antimicrobials is still needed. A small series of 3- amino/nitrocoumarins without substitutions or substituted by methyl or methoxy groups at different positions were synthesized and evaluated for their antibacterial and antifungal activities against clinical isolates of Staphylococcus aureus, Escherichia coli and Candida albicans strains. Some of these structurally simple molecules exhibited antibacterial activity. The preliminary SAR study showed that the antibacterial activity against E. coli and S. aureus was dependent on the kind and position of the substitution pattern at the coumarin moiety. © 2012 Bentham Science Publishers.

Language: English

Type (Professor's evaluation): Scientific