TET enzymes in neurophysiology and brain function

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Antunes, C (Author) Other; Sousa, N (Author) Other; Pinto, L (Author) Other; Joana Marques, CJ (Author) FMUP

Journal

Title: Neuroscience and Biobehavioral Reviews

Vol. 102

Pages: 337-344

ISSN: 0149-7634

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 31 Citations

Scopus - 35 Citations

Other information

Authenticus ID: P-00Q-M3J

DOI: 10.1016/j.neubiorev.2019.05.006

Abstract (EN): The dynamic nature of epigenetic DNA modifications is crucial for regulating gene expression in an experience dependent manner and, thus, a potential mediator of neuronal plasticity and behavior. The discovery of the involvement of 5-hydroxymethylcytosine (5hmC) and Ten Eleven Translocation (TET) family of enzymes in the demethylation pathway uncovered a potential link between neuronal TET protein function and cognitive processes. In this review, we provide an overview on how profile of 5hmC and TET enzymes are powerful mechanisms to explain neuronal plasticity and long-term behaviors, such as cognition. More specifically, we discuss how the current knowledge integrates the function of each TET enzyme in neurophysiology and brain function.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8