Production of vitamin B1 microparticles by a spray drying process using different biopolymers as wall materials

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Carlan, IC (Author) Other; Berta Nogueiro Estevinho (Author) FEUP; Fernando Rocha (Author) FEUP

Journal

Title: Canadian Journal of Chemical Engineering

Vol. 98

Pages: 1682-1695

ISSN: 0008-4034

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 5 Citations

Scientific classification

CORDIS: Technological sciences > Engineering

FOS: Engineering and technology

Associated Projects

MicroDelivery - Desenvolvimento de sistemas funcionais de libertação controlada por microencapsulação de compostos ativos e naturais, com interesse terapêutico, nutricional e tecnológico

Other information

Authenticus ID: P-00R-XTX

DOI: 10.1002/cjce.23735

Abstract (EN): The aim of this work was to microencapsulate vitamin B1 by spray-drying using different encapsulating agents (arabic gum, carrageenan, chitosan, maltodextrin, modified chitosan, modified starch, pectin, sodium alginate, and xanthan) and to characterize the microcapsules and study their release. Microcapsules with a 0.25% (w/w) content of vitamin B1 were produced. The product yield results ranged from 17%-52% and the encapsulation efficiency from 66%-100%. Three categories of morphology, regular spherical shape, irregular spherical shape with rough surface, and irregular shape, were identified. Their sizes, determined by laser granulometry, ranged from 0.11-1.32 mu m, in terms of number distribution, and from 3.76-34.43 mu m, in volume distribution. Controlled release studies were performed by spectrophotometric analysis, in deionized water (20 degrees C) and simulated gastric fluid (37 degrees C). Different release behaviours were observed from just 10 seconds (modified starch) up to more than 24 hours (xanthan). Kinetic models such as zero-order, first-order, Higuchi, Korsmeyer-Peppas, and Weibull were applied. The Weibull model showed the best fitting with the experimental data. All release tests were repeated after 4 months and showed good stability over time. A mass loss of vitamin B1 lower than 20% was detected. This study demonstrates the possibility of encapsulating vitamin B1 using different encapsulating agents by a spray-drying technique. Depending on the intended applications, for fast release, adequate results were obtained for maltodextrin, arabic gum, modified chitosan, and sodium alginate, and for slow release, adequate results were only obtained for chitosan and pectin.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14