The Dysfunctional Immune System in Common Variable Immunodeficiency Increases the Susceptibility to Gastric Cancer

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Gullo, I (Author) FMUP; Costa, C (Author) Other; Silva, SL (Author) Other; Ferreira, C (Author) Other; Motta, A (Author) Other; Silva, SP (Author) Other; Ferreira, RD (Author) Other; Rosmaninho, P (Author) Other; Faria, E (Author) Other; José Castela Costa (Author) FMUP; Camara, R (Author) Other; Goncalves, G (Author) Other; João Santos-Antunes (Author) FMUP; Oliveira, C (Author) Other; Machado JC (Author) FMUP; Carneiro F (Author) FMUP; Sousa, AE (Author) Other

Journal

Title: Cells

Vol. 9

Final page: 1498

ISSN: 2073-4409

Publisher: MDPI

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 3 Citations

Other information

Authenticus ID: P-00S-C6G

DOI: 10.3390/cells9061498

Abstract (EN): Gastric carcinoma (GC) represents the most common cause of death in patients with common variable immunodeficiency (CVID). However, a limited number of cases have been characterised so far. In this study, we analysed the clinical features, bacterial/viral infections, detailed morphology and immune microenvironment of nine CVID patients with GC. The study of the immune microenvironment included automated digital counts of CD20+, CD4+, CD8+, FOXP3+, GATA3+ and CD138+ immune cells, as well as the evaluation of PD-L1 expression. Twenty-one GCs from non-CVID patients were used as a control group. GC in CVID patients was diagnosed mostly at early-stage (n= 6/9; 66.7%) and at younger age (median-age: 43y), when compared to non-CVID patients (p< 0.001). GC pathogenesis was closely related toHelicobacter pyloriinfection (n= 8/9; 88.9%), but not to Epstein-Barr virus (0.0%) or cytomegalovirus infection (0.0%). Non-neoplastic mucosa (non-NM) in CVID-patients displayed prominent lymphocytic gastritis (100%) and a dysfunctional immune microenvironment, characterised by higher rates of CD4+/CD8+/Foxp3+/GATA3+/PD-L1+ immune cells and the expected paucity of CD20+ B-lymphocytes and CD138+ plasma cells, when compared to non-CVID patients (p< 0.05). Changes in the immune microenvironment between non-NM and GC were not equivalent in CVID and non-CVID patients, reflecting the relevance of immune dysfunction for gastric carcinogenesis and GC progression in the CVID population.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 21