Advanced chemometric modeling approaches for the design of multitarget drugs against neurodegenerative diseases

• Type: Chapter or Part of a Book
• Date: 2019

Authors

Halder, AK (Author) Other; Moura, AS (Author) Other; Natalia N D S Cordeiro (Author) FCUP

Indexing

Scopus - 3 Citations

Other information

Authenticus ID: P-00Q-1EV

DOI: 10.1007/7653_2018_14

Abstract (EN): Neurodegenerative diseases (ND), a major worldwide health problem, present a multifactorial nature. This implies that a multitargeted therapy approach can be considered more effective in such cases when comparing with ¿one drug-one target¿ based therapies. Multitarget drugs interact simultaneously with two or more therapeutic targets, thus acting synergistically to improve the disease conditions. This chapter discusses the recent advances in chemometric techniques in multitarget anti-ND drug design. After a brief introduction to the most relevant pathophysiological aspects of some common neurodegenerative diseases, it analyses not only pathophysiology versus therapeutic targets but also conventional versus novel chemometric techniques within such context. The emergence of novel and various chemometric techniques undoubtedly contributed to the design of multitarget-directed ligands (MTDLs) over the last decade, laying emphasis on the sound prospective for future therapeutics regarding diseases such as Alzheimer¿s and Parkinson¿s disease. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.

Language: English

Type (Professor's evaluation): Scientific