Abstract (EN):
Lignin nanoparticles (LNP) loaded with pyranoanthocyanin dimers (PD) and portisins (P) were produced using nanoprecipitation and dialysis techniques. The results obtained for LNP and P-LNP showed particles presenting sizes around 200 nm with a very narrow size distribution (PDI <= 0.2) using both methods. For PD-LNP, the nanoprecipitation method yielded particles with high particle sizes (Z-average approximate to 800 nm) and PDI approximate to 0.45 when compared to the dialysis method that produced particles with an average size around 200 rim and a PDI below 0.2. Concerning the average zeta potential (zeta), values around - 40 mV were obtained for both methods. TEM, SEM and STEM images showed that the particles present a spherical and compact shape and that these characteristics were maintained for 28 days at room temperature. High encapsulation efficiencies of 86 +/- 2 and 85 +/- 4 were observed for PD and P, respectively. LNP stability was followed at pH >= 5 for at least 7 days and the LNP encapsulated systems (PD-LNP and P-LNP) showed a good colour stability towards pH change after 8 days of incubation, when compared with the pure bluish pigments.
Language:
English
Type (Professor's evaluation):
Scientific
No. of pages:
8