Solvatochromism as a new tool to distinguish structurally similar compounds

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Pedro P. Madeira (Author) Other; Joana A. Loureiro (Author) FEUP; Mara G. Freire (Author) Other; João A. P. Coutinho (Author) Other

Journal

Title: Journal of Molecular Liquids

Vol. 274

Pages: 740-745

ISSN: 0167-7322

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 2 Citations

INSPEC

Other information

Authenticus ID: P-00P-X20

DOI: 10.1016/j.molliq.2018.11.050

Abstract (EN): It is here reported a new concept based on solvatochromism to distinguish structurally similar compounds in aqueous solutions by the analysis of the stabilization of electronic excited states. The sensitivity of this approach to differentiate similar organic compounds, such as structural isomers or compound differing in the number of methylene groups, or proteins with conformational changes induced by being or not bound to cofactors, differing in two amino acids substitutions, or differing in their glycosylation profile, is demonstrated. The sensitivity of the proposed approach, based on the solvatochromic method, opens the path to its use as an auxiliary analytical tool in biomedical diagnosis/prognosis or in quality control of biologic-based drugs.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6