Multifunctional graphene-based magnetic nanocarriers for combined hyperthermia and dual stimuli-responsive drug delivery

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Adrián M. T. Silva (Author) FEUP; Raquel O. Rodrigues (Author) FEUP; Giovanni Baldi (Author) Other; Saer Doumett (Author) Other; Lorena Garcia-Hevia (Author) Other; Juan Gallo (Author) Other; Manuel Bañobre-López (Author) Other; Goran Drazic (Author) Other; Ricardo C. Calhelha (Author) Other; Isabel C. F. R. Ferreira (Author) Other; Rui Lima (Author) Other; Helder T. Gomes (Author) Other

Journal

Title: Materials Science and Engineering C

Vol. 93

Pages: 206-217

ISSN: 0928-4931

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 6 Citations

ISI Web of Science

Scopus - 33 Citations

INSPEC

Scientific classification

CORDIS: Technological sciences

Other information

Authenticus ID: P-00P-DZE

DOI: 10.1016/j.msec.2018.07.060

Abstract (EN): The synthesis of hydrophilic graphene-based yolk-shell magnetic nanoparticles functionalized with copolymer pluronic F-127 (GYSMNP@PF127) is herein reported to achieve an efficient multifunctional biomedical system for mild hyperthermia and stimuli-responsive drug delivery. In vitro tests revealed the extraordinary ability of GYSMNP@PF127 to act as smart stimuli-responsive multifunctional nanomedicine platform for cancer therapy, exhibiting (i) an outstanding loading capacity of 91% (w/w, representing 910 mu g mg(-1)) of the chemotherapeutic drug doxorubicin, (ii) a high heating efficiency under an alternating (AC) magnetic field (intrinsic power loss ranging from 2.1-2.7 nHm(2) kg(-1)), and (iii) a dual pH and thermal stimuli-responsive drug controlled release (46% at acidic tumour pH vs 7% at physiological pH) under AC magnetic field, in just 30 (nth. Additionally, GYSMNP@PF127 presents optimal hydrodynamic diameter (D-H = 180 mn) with negative surface charge, high haemocompatibility for blood stream applications and tumour cellular uptake of drug nanocarriers. Due to its physicochemical, magnetic and biocompatibility properties, the developed graphene-based magnetic nano carrier shows high promise as dual exogenous (AC field)/endogenous (pH) stimuli-responsive actuators for targeted thermo-chemotherapy, combining magnetic hyperthermia and controlled drug release triggered by the abnormal tumour environment. The presented strategy and findings can represent a new way to design and develop highly stable added-value graphene-based nanostructures for the combined treatment of cancer.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12