Curcumin and Rutin Down-regulate Cyclooxygenase-2 and Reduce Tumor-associated Inflammation in HPV16-Transgenic Mice

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Magda S. S. Moutinho (Author) Other; Sofia Aragão (Author) Other; Diogo Carmo (Author) Other; Fátima Casaca (Author) Other; Sandra Silva (Author) Other; Joana Ribeiro (Author) Other; Hugo Sousa (Author) Other; Isabel Pires (Author) Other; Felisbina Queiroga (Author) Other; Bruno Colaço (Author) Other; Rui Medeiros (Author) Other; Paula A. Oliveira (Author) Other; Carlos Lopes (Author) Other; Margarida M. S. M. Bastos (Author) FEUP; Rui M. Gil da Costa Oliveira (Author) FEUP

Journal

Title: Anticancer Research

Serial No. 3 Vol. 38

Pages: 1461-1466

ISSN: 0250-7005

Publisher: International Institute of Anticancer Research

Indexing

ISI Web of Knowledge - 25 Citations

Scopus - 35 Citations

Associated Projects

LEPABE - Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia

Other information

Authenticus ID: P-00N-R0C

DOI: 10.21873/anticanres.12371

Abstract (EN): Aim: Cyclo-oxygenase-2 (COX2) plays a prominent role in carcinogenesis. This study addresses the effects of two nutraceutical compounds on the expression of COX2 and tumor-associated inflammation in human papillomavirus type 16 (HPV16)-transgenic mice. Materials and Methods: Six-week - old FVB/n mice were supplemented with rutin or curcumin for 24 weeks: HPV16(-/-) no treatment, n=12; HPV16(+/-) no treatment, n=13; HPV16(+/-) rutin, n=12; HPV16(+/-) curcumin, n=13. HPV16-induced skin lesions and their inflammatory infiltrates were studied histologically. COX2 expression was assessed immunohistochemically. Results: Rutin reduced COX2 expression in the dermis (immunostaining score 7.83 versus 11.25 in untreated HPV16-transgenic mice) and epidermis (4.5 versus 10.0). Curcumin led to dermal and epidermal scores of 10.5 and 4.5. Both compounds reduced leukocytic infiltration, but neither prevented epidermal dysplasia. Conclusion: COX2 expression in HPV16-induced lesions may be modulated by nutraceuticals, reducing tumor-associated inflammation. However, this was not sufficient to block carcinogenesis, calling for additional studies focused on combination therapies.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6